Endocrine Abstracts

Background: PCBs are chemical pollutants able to promote inflammation and carcinogenesis. They can accumulate in human tissues through the food chain causing a variety of adverse health effects. The NF-E2 p45-related factor 2 (NRF2) and the aryl hydrocarbon receptor (AHR) are ligand activated transcription factors controlling pathways modulating xenobiotic metabolism. Increasing evidence indicate the involvement of AhR in regulating extracellular matrix (ECM) homeostasis. ECM ...